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Expert Rev Clin Immunol

In contrast, an overdose of APAP causes hepatotoxicity by saturating the sulfation pathway and generating NAPQI that leads to a robust reaction between NAPQI and hepatic glutathione stores, which subsequently depletes glutathione (Xie et al., 2015)

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57,127,128 Suppressing NLRP3 inflammasome activation, ASC speck formation, caspase-1 activation, and IL-1 maturation alleviates acute liver injury caused by APAP poisoning

Figure 7: Chronic liver disease (steatosis, steatohepatitis, and cirrhosis) is linked to excess inflammatory proteins and fat deposits, which disrupt energy production and metabolism