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UK prescribers and patients now have substantial real-world experience with titration, injection technique, missed-dose rules, and follow-up, alongside the SURPASS trial programme that supported licensing

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Multiple thrombectomy passes have also been independently associated with a significant increase in BBB disruption as evaluated by hyperintense acute reperfusion marker (HARM) which is a hyperintensity on T2-weighted fluid-attenuated inversion recovery (FLAIR) MRI following an injection of gadolinium-based contrast agent (149)

GPBAR1, also known as TGR5, is activated by both primary and secondary BAs

The 32mg pen suits shorter pilot studies or low-dose tolerability work where total mg requirements stay under approximately 30mg across the run