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Absorption, metabolism, and functions of hyaluronic acid and its therapeutic prospects in combination with microorganisms: a review

This approach not only facilitates the delivery of DSIP into the brain but also highlights the potential of brain-homing peptides as effective carriers for small molecule drugs, targeting brain parenchyma directly and efficiently

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Established chemotherapy drugs, such as methotrexate, directly inhibit key enzymes but often cause significant systemic adverse effects 36,37

Similarly, ER-mitochondria associations and VAPB-PTPIP51 interactions are disrupted by ALS-associated mutant FUS (Stoica et al., 2016), which results in increased production of ROS