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A prodrug nanoparticle synthesized by conjugating PD-L1Pep-2 with doxorubicin via cathepsin B-cleavable peptide linker (FRRG) inhibited tumor progression in the 4T1 mouse breast tumor model by inducing doxorubicin-mediated immunogenic cell death and blocking PD-L1 through PD-L1Pep-2 102
Key References Sikiric P, et al
F, female
Many articles in this study indicated the patients included had adequately followed these guidelines, some indicating patients fasting well beyond the recommended guidelines, and still noted either increased residual gastric contents, aspiration events, or other GI-related symptoms in the perioperative setting (Santos et al
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