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In a research note Bernstein analyst Timothy Anderson wrote that the TECOS news removes "a psychological overhang" from the drug and leaves Januvia as "the best-positioned DPP4 in the category," which may allow it to "pick up at least some market share from its direct competitors." At this point, however, some caution may be warranted

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342 The tri-agonist lowered body weight in diet-induced obese mice by 26.6% after 20 days of treatment, whereas the GLP-1R/GIPR coagonist lowered body weight by 15.7%, and it was found that the action of the tri-agonist occurred in a dose-dependent manner

1 Introduction Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are two naturally occurring hormonal peptides produced in gastrointestinal tract, knowns as incretins