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In a trial by Iepsen et al., 37 women with an average age of 46 (Standard Deviation: 2 years, range 18-65 years) and BMI of 34 (SD: 0.5 kg/m 2 ) achieved a 12% weight loss after 8 weeks of low-calorie diet modifications

The cyclic lactam structure that defines MT-II has served as a template for subsequent melanocortin-receptor probe development, including the receptor-selective antagonist series reported by Hruby and colleagues in 1995 using bulky aromatic substitutions at position 7 [8]

Fiber, which can help manage constipation that many GLP-1 users experience, is not included in meaningful amounts