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SURMOUNT-4: placebo group regained +14.0% body weight over 52 weeks, with only 16.6% maintaining 80% of loss

The recovery of peptidemRNA fusion molecules was significantly increased following four and five rounds of selection using the L- and D-libraries, respectively (as compared with the background recovery resulting from nonspecific binding to the magnetic beads alone

That may mean improving total energy and protein intake, correcting a documented deficiency, controlling gastrointestinal adverse effects, treating thyroid or scalp disease, or addressing another contributing medication or illness