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have found out that elevated levels of ROS in pancreatic -cells inhibit the pancreas duodenum homeobox-1 (PDX-1) transcription factor that is needed for insulin synthesis (98)

Furthermore, in transgenic mouse models expressing human -syn, hepatic -syn protein levels exhibit time-dependent accumulation despite the absence of -syn mRNA expression in the liver under neuron-specific promoter regulation, suggesting a potential neural system-derived origin of the protein [57]

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Notes 5-Amino-1MQ is a small molecule (not a peptide) inhibiting NNMT

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