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Oxidative stress and low glutathione in common ear, nose, and throat conditions: a systematic review

These results suggest that hNPCs have similar capacity to engage NRF2 transcriptional pathways

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Moreover, a minor proportion of this agent can be metabolized within the liver by the cytochrome P450 enzymes (primarily by CYP2E1) to NAPQI, which is detoxified by conjugation and excreted in the glutathione or NAC forms ( Figure 2 )