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The first publications reported enzyme activity involving displacement of a halide ion from an aromatic compound, resulting in an S-substituted glutathione conjugate ( GSTs were first recognized as enzymes inactivating xenobiotics, in particular electrophilic mutagens and carcinogens, leading to their excretion as mercapturic acids ( An independent set of reports identified a remarkably abundant protein in liver with affinity for carcinogens, steroid hormones, bilirubin and synthetic dyes

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Think of it as a gradual, steady process rather than something that happens overnight

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Batista AF, Forny-Germano L, Clarke JR, Lyra ESNM, Brito-Moreira J, Boehnke SE, et al