Freezing a liquid peptide solution can destroy its structure
Whilst GLP-1 receptor agonists such as semaglutide and liraglutide have demonstrated significant effects on blood glucose control and body weight, there is currently no established evidence that these medications directly treat hot flashes
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While the findings are compelling, they should be interpreted in the context of limitations inherent to retrospective [electronic health record]-based analyses, including potential residual confounding and lack of procedural-level details
This is in concordance with preclinical data in rodents and nonhuman primates showing expression of GLP1Rs in brain regions involved in reward and addiction, for example, VTA, NAc, septal nucleus, hypothalamus and amygdala [35, 36, 37, 38, 39, 40]