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As shown in Figure 9B, the common targets of main ingredients and AD in FRP are mainly enriched in signal transduction, positive regulation of transcription from RNA polymerase II promoter, protein phosphorylation, negative regulation of the apoptotic process, response to the drug, positive regulation of gene expression, positive regulation of cell proliferation, response to xenobiotic stimulus, positive regulation of transcription, DNA-templated, positive regulation of MAPK cascade

doi: 10.3390/molecules28124828 53

Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology

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The co-primary endpoints were the percentage change in body weight and achievement of weight loss of 5% at week 104