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PMID: 11713213.] Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R

Also, xCT is mainly responsible for cystine/glutamate exchange and highly specific to Cys and glutamate ( c is inhibited, the production of GSH is decreased and the level of ROS and lipid peroxidation is increased, thereby leading to the occurrence of ferroptosis ( Glutathione exists in two formsreduced (GSH) and oxidized (GSSG)and the ratio of the two forms (GSSG/GSH) indicates the degree of oxidative stress in cells (Figure 3)

This results in lower expression of cytokines (TNF-, IL-6, etc.) and adhesion molecules, dampening the vascular inflammation that drives atherosclerosis and hypertensive organ damage (Wang Q

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Interestingly, we consistently observed downregulation of RRM2 at the protein level across all single and combination treatments