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These metabolic effects can have positive implications beyond weight loss and blood sugar control, contributing to overall metabolic health [3]

My depression got worse

Tirzepatide users in the SURMOUNT-1 trial lost up to 22.5% of body weight, substantially more than semaglutide STEP trial results

Working with your healthcare provider, you can find the lowest effective maintenance dose that keeps you at your target weight and health metrics

Without ongoing support, such as nutrition planning, strength training, medical follow-up, or a supervised tapering plan, hunger and cravings may return, making weight regain more likely