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Harm to our natural GLP-1 pathway

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For example, Df1/+ mice have deficits in sensorimotor gating and psychostimulant induced hyper-locomotion, as well as motor coordination deficits, elevated alpha synuclein and p62 proteins in multiple brain regions, showing pleiotropy for SSD and Parkinsons disease-relevant phenotypes (Table 1

We found that pharmacological MT1 and MT2 agonism failed to replicate the effects of melatonin in suppressing IL-5 production ( Figures 3B, D ) or IL-13 production ( Figures 3C, E )