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Their 7-TMD structure involves intimate interactions with plasma membrane lipids (15), known to be non-homogeneously distributed but rather organised in regions known as lipid nanodomains or lipid rafts, enriched in lipid species including sphingolipids and cholesterol, as well as in integral membrane proteins serving as scaffolds for signal transduction (17, 18), and GPCR trafficking and sorting (15, 19, 20)

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A doctor may recommend vitamin B12 shots for people at risk of a deficiency or its complications, particularly if they are unable to take oral supplements