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Thus, heterosynaptic changes in inhibitory neurons were weight-dependent: Inputs with initially high paired-pulse ratio (low release probability, weak inputs) tended to be potentiated while inputs with initially low paired-pulse ratio (high release probability, strong synapses) tended to depress or did not change after intracellular tetanization

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doi: 10.3390/ijms20061475

This makes cagrilintide a potentially better option for individuals who found vomiting intolerable on GLP-1 medications

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