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It's a vicious cycle

Sarcopenic obesity, which combines obesity and sarcopenia, is concerning and is associated with reduced quality of life and elevated risk of falls, cardiovascular disease, and mortality

Its currently in US clinical trials which are expected to run until 2026, so it isnt available yet

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However, the cognitive enhancing effects of PregS in healthy subjects are unlikely to be due to the PREG metabolite ALLO since acute administration of this and other GABAergic modulating neurosteroids to healthy subjects inhibits learning and memory function in a manner similar to benzodiazepines (187191)