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In the adjuvant arthritis (tail-application of 0.2 ml of Freund's adjuvant) studies (14 days, 30 days, one year), NaBPC157 (10 g or 10 ng/kg i.p.) was given as a single application (at 1 hour either before or following the application of Freund's adjuvant) or in a once-daily regimen (0-14 th day, 14-30 th day and 14 th day-one year)