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Since most reactions in the second stage are spontaneous, tyrosinase acts as the rate-limiting enzyme in melanin synthesis, making it the primary enzyme involved in both enzymatic browning and melanin production 7

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Glucomannan, in particular, is known for its powerful appetite-suppressing effects

20 studies were assessed for risk of bias using the Cochrane Risk of Bias assessment tool (Rob2.0) and were finally selected for data extraction and qualitative analysis