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2024 TriNetX database analysis showed lower suicide risk in GLP-1 users versus non-users GLP-1s affect brain regions controlling impulse and futuristic thinking same mechanisms through which clozapine, lithium, and ketamine reduce suicidal behavior Not all GLP-1 agents are equivalent

Gastrointestinal symptoms Tongue soreness, appetite loss, and constipation have also been associated with vitamin B 12 deficiency