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One challenge with GLP-1 medications is that appetite drops so much, its easy to fall short on key nutrients especially protein
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Moreover, phospho-BCL-XL (Ser62) stabilizes G2 arrest by binding to and co-localizing with Cdk1 (cdc2) in nucleolar structures to avoid rapid nucleolar disassembly associated with mitosis onset, playing an unexpected role in the G2 phase checkpoint downstream of DNA damage distinct from its anti-apoptotic function 22
Additionally, the expression of certain microRNAs, such as miR-137 and miR-9, has been found to regulate ferroptosis in melanoma by targeting glutamate metabolism, which could have implications for therapy resistance and sensitivity
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