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Bile acids also promote colonic water secretion, through TGR5-mediated activation of adenylate cyclase, which stimulates chloride secretion through the cystic fibrosis transmembrane conductance regulator (CFTR) (174)

The glucagon receptor is primarily expressed in the liver but also in the central nervous system, kidney, gastrointestinal tract and pancreas [49, 50]

The financial disparity between NHS and private access creates significant health inequalities, with treatment largely accessible only to those who can afford private costs

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doi: 10.1016/j.rdc.2007.01.003 80 KhamashtaMA