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ACE-031 is a recombinant fusion protein originally developed as a clinical candidate

However, the underlying mechanisms remain incompletely understood and require further investigation

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[18] GtmA catalyzes the addition of methyl groups to the sulfur residues of dithiol gliotoxin to form nontoxic BmGT, which reduces the toxicity load on the fungi while also downregulating further expression of the gli cluster and attenuating gliotoxin biosynthesis

CJC-1295 without DAC (Mod GRF 1-29) has a 25 to 30-minute half-life and is dosed at 100 to 300 mcg one to three times daily