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If you are under significant physical or mental stress, your bodys "burn rate" for antioxidants increases

427 Therefore, acetazolamide is not routinely recommended for treating AMS and HACE

The suppression of antioxidant proteins, glutathione synthesis enzymes, and NADPH-producing enzymes would lead to ROS accumulation in cancer cells and subsequent oxidative damage to various intracellular components, thus compromising the cell viability

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It does not have extensive human clinical trial data demonstrating safety and efficacy for specific medical conditions