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Previous research has demonstrated that TRIM28 facilitates GC deterioration by suppressing PD-L1 ubiquitination and activating the TBKI-IRF1 and TBK1-mTOR signaling pathways, thereby increasing the stability and expression of PD-L1 [28]

References: Falutz, J., Allas, S., Blot, K., Potvin, D., Kotler, D., Somero, M., Berger, D., Brown, S., Richmond, G., Fessel, J., Turner, R., & Grinspoon, S

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