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Metabolic adaptation reduces basal metabolic rate and non-exercise activity thermogenesis when calorie intake decreases, lowering total energy expenditure

*JAMA*, 281(15), 1415-1423

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[3] [4] Clinical trials have demonstrated substantial reductions in hemoglobin A1c (up to 2.5% reduction from baseline) and body weight (up to 20% reduction from baseline) in the SURPASS and SURMOUNT clinical trial programs

This underscores that mimicking a more physiological environment enables a more accurate representation of pathogenic potential in in vitro infection models