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In people with obesity, less liver fat translates to a whole body ability to manage blood sugar and insulin sensitivity
26, 27 GPx activity was slightly but not significantly lower in SHR at 2 weeks of age when compared with WKY rats (Figure 3) and whether the slightly lower GPx activity at 2 weeks of age and afterward was due to the overexpression of CAT or vice versa in this study is uncertain
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Although not specifically studied in MetALD, traditional prognostic scores such as Child-Pugh and the model for end-stage liver disease (MELD) remain applicable once MetALD progresses to established cirrhosis, as they capture downstream consequences of portal hypertension and hepatic synthetic dysfunction that are largely etiology agnostic
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