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Through rational medicinal chemistry approaches, the development of inhibitors with high affinity and selectivity against ASCT2 is possible

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The human GST multi-gene superfamily is encoding for various ubiquitous cytosolic or soluble, mitochondrial and microsomal as well as peroxisomal homo- and heterodimeric transferases ( S -conjugation generates a less or non-toxic product with improved water solubility, favoring the exportation out of the cell and thereby contributing to DNA damage prevention and protection of the cellular integrity (Wang et al., 2001

Clinicians using the stack therefore tend to reduce individual doses (e.g., 100 mcg sermorelin plus 100 mcg CJC-1295 no DAC per injection) rather than doubling full doses