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280,281,282 Therefore, pioglitazone has been recommended as the preferred drug

This intracellular conversion has been confirmed pharmacokinetically: in a peer-reviewed human bioavailability crossover trial, SAG was undetectable in plasma following oral administration because rapid deacetylation occurs before or immediately upon systemic entry meaning the entire SAG load is converted to GSH before reaching blood circulation

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Across studies, these models yield an average AUC value of ~ 0.700.75, indicating a substantial but not conclusive illness signal

But here is the critical caveat