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However, after 40 to 42 weeks, no significant difference in estimated glomerular filtration rate was observed

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Even if all 3 trials were designed to primarily prove the safety of DPP-4 inhibitors, that is, noninferiority versus placebo, SAVOR-TIMI 53 and TECOS were powered to test superiority if the criterion of noninferiority was met

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563 Monitoring and considerations include dose titration, initiating medications at low doses and gradually increasing to the maximum tolerated dose while monitoring efficacy and adverse effects