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For obesity treatment, higher maintenance doses within the labeled range consistently produce the greatest, most long-term weight loss in randomized trials: Semaglutide 2.4 mg led to about 15 percent average weight loss at 68 weeks in STEP trials

I suggest that clients eat smaller and more frequent meals, avoid high fat and greasy foods, increase fiber gradually, and stay hydrated, says Rita Restivo, RD

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Medical conditions such as polycystic ovary syndrome (PCOS), Cushing's syndrome, or hypothyroidism may also impede progress and warrant evaluation if suspected

More activity means more caloric expenditure and better muscle preservation