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Therefore, multi-targeting or unimolecular peptides possessing combinatorial agonism at GIPR, GLP-1R and GCGR have been extensively explored and more than a dozen peptides including two GIPR/GLP-1R dual agonists, ten GLP-1R/GCGR dual agonists and five GIPR/GLP-1R/GCGR triagonists have entered into clinical development (Supplementary Fig

Understanding these mechanisms provides the foundation for exploring therapeutic interventions that might support cellular health throughout the aging process

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2023;135(25):e202303973

Wolman Disease (LIPA p.G87V) Genotype Frequency in People of Iranian-Jewish Ancestry