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Women over 50 on GLP-1s are dealing with three compounding challenges: age-related muscle loss, menopause-related bone density changes, and the additional muscle loss from the medication itself

Clin Kidney J

These medicines can lead to even more weight loss about a 10% to 20% drop in body weight after a year

NADA ROJO NI MORADO

Common side effects during the adjustment period (typically the first 24 weeks): Mild nausea usually less intense than when first starting a GLP-1 medication Changes in appetite (some patients notice less appetite suppression early on at the starting 0.25 mg dose) Mild stomach discomfort, bloating, or constipation Injection site reactions Side effects that are less likely during the switch (compared to first-time GLP-1 use), but still possible: Significant vomiting less common given prior GLP-1 exposure, but possible Hypoglycemia particularly relevant for type 2 diabetes patients on insulin or sulfonylureas