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HIF-1 activates glycolysis-related genes, including pyruvate dehydrogenase kinase 1 (PDK1), increasing the conversion of glucose to pyruvate and subsequently to lactate by inactivating PDH, which is considered critical for metabolic adaptation to hypoxia [74] [Figure 1F]

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Hydroalcoholic extract of sechium edule fruits attenuates QT prolongation in high fat diet-induced hyperlipidemic mice