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Inhibition of mTORC1 enhances the polarization of M1 macrophages, whereas TSC1 deletion increases the activity of mTORC1 and reduces mTORC2 activity to promote the polarization of M1 and decrease M2 macrophage polarization [86, 87]

Acknowledgements We extend our gratitude to Farnaz Hemmati and Farshad Amiri from Auburn University for their diligent efforts in meticulously reviewing the schematics

Epitalon can bind certain DNA sequences, particularly with CAG sequences, which are susceptible to DNA cytosine methylation [20]