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Natural compounds and TCM formulas [e.g., berberine and irisflorentin (201, 202)] show efficacy, but their active ingredients, direct molecular targets, and standardized formulations are poorly defined, hindering clinical development

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The possible negative influence of different doses of progoitrin on the thyroid was evaluated in humans using acute inhibition of radioiodine uptake, as well as 24 h uptake, by Greer et al

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For muscle pain, several strategies may help alleviate discomfort: Hydration and Nutrition: Ensuring adequate fluid intake and balanced electrolytes can reduce muscle cramps and soreness