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Of the group, tesamorelin has the strongest human data

Studies have documented changes in IGFBP levels with chronic IGF1 LR3 use, which may influence the overall growth factor milieu

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Native IGF-1 (mecasermin) has been through the full regulatory pipeline: dose-ranging studies, controlled trials in the target population, characterized pharmacokinetics, a defined adverse-event profile, and ongoing post-marketing surveillance