A 2021 study by Zerbinati and colleagues tested a serum with 30% 3-O-ethyl-l-ascorbic acid and 1% lactic acid significantly increased collagen production, reduced UVB-induced DNA damage, and decreased melanin on a reconstructed pigmented skin model
BOX 7-2 Ways to Classify Melanocytic Nevi Onset Congenital: present at birth or soon thereafter Acquired: occurs after 6 months old Location of Nevus Cells Epidermal: arising in the epidermis only Junctional: arising at the dermal-epidermal junction Dermal: nests in the dermis or subcutaneous fat only Compound: a combination of junctional and dermal Type of Cells Melanocytic: melanocytes only Spindle cell: spindle-shaped cells as in Spitz nevus Blue pigmented cells: Cellular blue nevi The subtypes of nevi can be classified in several ways, including onset of the lesion, location of the nested cells, and type of cells (Box 7-2)
If you don't feel appetite suppression after 4-6 weeks at a stable dose, tolerance may be developing or your dose may be insufficient
If the diagnosis is not unmistakable or there is evidence of any allergic condition underlying the perleche, a dermatologic consultation should be asked for
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