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In addition, NOR also inhibited the reduction of AhR/NF-B/p65 complex caused by nuclear translocation of NF-B p65 in osteoclasts, and reduced the expression of VEGF, resulting in the reduction of accumulation of ARNT/HIF-1 complex, suggesting that NOR reduced osteoclast differentiation and bone erosion by activating AhR and inhibiting the subsequent NF-B and HIF pathways (81)