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Women over 40 face unique weight-loss challenges including declining estrogen, loss of muscle mass, and increased insulin resistance GLP-1 medications show strong efficacy in women over 40, with clinical trial data showing no significant difference in response by age group Phentermine and Contrave remain effective options, though cardiovascular screening is more important as women age PEAK tailors medication selection to each patients hormonal status, metabolic profile, and health history For many women, the 40s mark a turning point in weight management

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Chou, H.-W