doi: 10.3389/fphar.2022.1024292 33 ZhangJShengSWangWDaiJZhongYRenJet al
Your healthcare provider may suggest that you lower your dose or even stop using the GLP-1 drug until you feel better
Its main active ingredient, total dajizin triterpenes, reduces the expression of ACSL4 in the rat model of RA, increases the expression of glutathione and GPX4, and upregulates Kelch-like ECH-associated protein 1 and HO-1 in the Nrf2/HO-1/GPX4 pathway, indicating that total dajizin triterpenes can inhibit cell aberrant ferroptosis by suppressing lipid peroxidation and thus exert therapeutic anti-RA effects [168]
As the patient works toward discontinuation of the medication, the importance of a healthy musculoskeletal system for maintaining healthy glucose metabolism and the downstream effects on systemic inflammation, insulin regulation, and metabolism is paramount
Long-term safety data exists primarily for standard therapeutic doses, not for sustained low-dose use