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Although the effects of NRF2 in ferroptosis are primarily directed at upregulating the GPX4 pathway, NRF2 also plays a role in iron metabolism, namely by promoting iron storage by ferritin [56]
tachycardia, tachypnoea, altered level of consciousness presence of risk factors features of underlying cause INVESTIGATIONS high anion gap metabolic acidosis (HAGMA) on blood gas normal osmolar gap normal lactate normal beta-hydroxybutyrate high pyroglutamic acid (urine or blood) MANAGEMENT stop exacerbating factors treat sepsis, including: early and appropriate antibiotics source control supportive care and monitoring intubation, ventilation, renal replacement therapy (RRT) as indicated N-acetylcysteine help replenish glutathione stores References and Links LITFL Metabolic Muddle 004 Staph sepsis and an unusual metabolic acidosis Journal articles Dempsey GA, Lyall HJ, Corke CF, & Scheinkestel CD (2000)
[7] [8] However, much of the mechanistic evidence underpinning these effects remains preclinical or derived from early-phase studies, and definitive human data are still awaited
How to Store Dry Peptides Dry peptides are typically in a solid, powdery form and are one of the most stable peptide formats
