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However, rapid fat loss can come with unwanted lean-mass reduction (up to 25-39% of total weight loss) as fat-free mass in some trials

Using an extensively validated monoclonal antibody, one landmark study mapped the receptor to beta cells in the pancreas, the myocytes of the sinoatrial node in the heart, and the smooth muscle of arteries and arterioles in the kidney and lung

Prognosis [edit] An elevation in serum bilirubin level of more than 2 times ULN with associated transaminase rise indicates severe hepatotoxicity and is likely to lead to mortality in 10% to 15% of patients, especially if the offending drug is not stopped (Hy's Law)