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GHK-Cu has been shown to modulate the expression of thousands of genes related to extracellular matrix (ECM) turnover, oxidative stress responses, and proteostasis through its interaction with the ubiquitin-proteasome system (Pickart and Margolina 2018

Running a GHK-Cu protocol alongside a progressive resistance training program is a particularly effective combination because you are building the structural support from both sides: GHK-Cu strengthens the skin matrix from the inside while muscle provides physical volume underneath