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In addition, its needed for proper immune function and cellular signaling

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These effects are mediated through GH-stimulated lipolysis, IGF-1-mediated muscle protein synthesis, and the anabolic effects of GH on connective tissue including collagen, tendons, and cartilage

54,55 Cardiovascular disease risk factors (CVDR), including age, gender, obesity, smoking, hypertension, diabetes mellitus, hyperlipidemia, dyslipidemia, and insulin-resistance, are the most significant independent CVD risks (CVDR)