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Think of it as your pets emergency alarm system when their body spots something it thinks is dangerous, such as pollen, dust, mold, or certain foods, histamine gets released as a first line of defense

It is (in general) fully plateaued with daily intake of 100 g and serum/plasma levels of 70130 or 90140 g/L (depending on the study), and the concentrations of ~5.5 mg/L (measured by ELISA) were associated with the Se sufficiency (e.g., among the USA population)

Epilepsy Res 106(12):5463 de Souza AG, Chaves Filho AJM, Souza Oliveira JV, de Souza DAA, Lopes IS, de Carvalho MAJ, de Lima KA, Floreno Sousa FC, Mendes Vasconcelos SM, Macedo D (2019) and M

Insufficient dietary substrates for microbial synthesis of short chain fatty acids including butyrate, may promote obesity [215]

This observation, combined with evidence that older adults have blunted MOTS-c responses to exercise, supports the hypothesis that declining mitochondrial peptide signaling contributes to the reduced exercise adaptability seen in aging