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4.2 Potential pathologic link between depression and ferroptosis 4.2.1 Iron deposition and neuroinflammation Neuroinflammation refers to the immune response of the central nervous system (CNS) mediated mainly by microglia and astrocytes in the hippocampus (UZUNGIL et al., 2022), have been implicated in depression associated with abnormal glial activation and iron overload, suggesting a potential connection between iron and neuroinflammation (ZENG et al., 2023)

A majority of the reported events occurred in patients who had experienced nausea, vomiting, diarrhea, or dehydration