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To account for the pronounced heterogeneity of the preclinical evidence base, specific inclusion criteria for preclinical studies were defined as follows: (1) Model Type: utilization of established in vivo models (e.g., transgenic AD models like APP/PS1 or 3xTg-AD, neurotoxin-induced PD models, middle cerebral artery occlusion for ischemia, or high-fat diet for metabolic dysfunction) or relevant in vitro neuronal/glial cell lines

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The mechanism works like this: DHT binds to androgen receptors on dermal papilla cells, the specialized fibroblasts at the base of each hair follicle that regulate hair growth cycling and follicle health

Conclusion Collectively, we unveil GPR68 as a critical sensor of ischemic acidosis that orchestrates ferroptosis resistance via PI3K/Akt/Nrf2 signaling

pylori or AGS cell pellets were thawed on ice and resuspended in 500 L ice-cold thiol extraction buffer (50% (v/v) acetonitrile (ACN