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Here are some possible future research directions for RA treatment: precision medicine and personalized therapy with specific biomarkers and genetic variations and/or epigenetic modifications, development of novel targets and mechanisms of RA, new drug formats (bispecific antibodies, improve targeting and reduce side effects), and most of all combination therapy of kinds targets and drugs

The metabolomic analysis was performed by following the Chemical Isotope Labeling (CIL) LC-MS protocol described in our previous report (81)

16 , e1008539 (2020)

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